Most played cards in Smallpox:

1 Decks
 ↓ Thoughtseize
4 copies – 4 avg
↓ Mishra's Factory
4 copies – 4 avg
↓ Leyline of the Void
4 copies – 4 avg
↓ Smallpox
4 copies – 4 avg
↓ Liliana of the Veil
4 copies – 4 avg
↓ Dark Ritual
4 copies – 4 avg
↓ Urborg, Tomb of Yawgmoth
4 copies – 4 avg
↓ Wasteland
4 copies – 4 avg
↓ Orcish Bowmasters
3 copies – 3 avg
↓ Ensnaring Bridge
3 copies – 3 avg
↓ Snow-Covered Swamp
3 copies – 3 avg
↓ Castle Locthwain
2 copies – 2 avg
↓ Innocent Blood
2 copies – 2 avg
↓ Opposition Agent
2 copies – 2 avg
↓ Torpor Orb
2 copies – 2 avg
↓ Chains of Mephistopheles
2 copies – 2 avg
↓ Sheoldred's Edict
2 copies – 2 avg
↓ Urza's Saga
2 copies – 2 avg
↓ Karn, the Great Creator
2 copies – 2 avg
↓ Expedition Map
1 copies – 1 avg